反应详情

Under a nitrogen atmosphere, a stirred solution of 0.5 gram (0.002 mole) of 2,4,7-triamino-6-(2-chlorophenyl)pteridine (prepared in Example 2) in 50 mL of N,N-dimethylformamide dimethylacetal was heated at reflux for about 5 hours. After this time the reaction mixture was cooled in an ice-bath, and a solid was collected by filtration. The solid was washed with diethyl ether, yielding, when dried, 0.5 gram of 2,4,7-tri-(dimethylaminomethyleneamino)-6-(2-chlorophenyl)pteridine. The NMR spectrum was consistent with the proposed structure.

1. temperatureat reflux for about 5 hours
2. temperatureAfter this time the reaction mixture was cooled in an ice-bath
3. filtrationa solid was collected by filtration
4. washThe solid was washed with diethyl ether
5. customyielding
6. customwhen dried