Carbonic acid-guanidine (1:1) → HCID 15278936, compound

HRID 1734153Notes

Reaction equation

HRID 1734153 reaction equation
N[C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=2)=[C:4]([CH3:24])[N:3]=1.C(=O)(O)O.[NH2:29][C:30]([NH2:32])=[NH:31]>CN(C)C(=O)C>[NH2:31][C:30]1[N:32]=[C:8]([NH2:9])[C:7]2[C:2](=[N:3][C:4]([CH3:24])=[C:5]([C:10]3[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:22])([F:21])[F:23])[CH:11]=3)[N:6]=2)[N:29]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 15335270HCID 15335270, compound

Product 1

HCID 15278936HCID 15278936, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

This compound is prepared in a manner analogous to that of Step B of Example 4, using 1.1 grams (0.003 mole) of 2-amino-3-cyano-5-[3,5-di(trifluoromethyl)phenyl]-6-methylpyrazine and 1.3 grams (0.007 mole) of guanidine carbonate in 10 mL of N,N-dimethylacetamide, yielding 2,4-diamino-6-[3,5-di(trifluoromethyl)phenyl]-7-methylpteridine.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step B of Example 4

Sources & evidence

ORD record
ord-d8df4b9d6bef45b18d8433aa2d626ba3
Source dataset
uspto-grants-1996_07
Patent number
US05532367

Reaction notes

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