Carbonic acid-guanidine (1:1) → HCID 15278937, compound

HRID 1734155Notes

Reaction equation

HRID 1734155 reaction equation
N[C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[C:12]([Cl:17])[CH:11]=2)=[CH:4][N:3]=1.C(=O)(O)O.[NH2:22][C:23]([NH2:25])=[NH:24]>CN(C)C(=O)C>[NH2:24][C:23]1[N:25]=[C:8]([NH2:9])[C:7]2[C:2](=[N:3][CH:4]=[C:5]([C:10]3[CH:15]=[C:14]([Cl:16])[CH:13]=[C:12]([Cl:17])[CH:11]=3)[N:6]=2)[N:22]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 19040794HCID 19040794, compound

Product 1

HCID 15278937HCID 15278937, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

This compound is prepared in a manner analogous to that of Step B of Example 4, using 0.8 gram (0.003 mole) of 2-amino-3-cyano-5-(3,5-dichlorophenyl)pyrazine and 1.3 grams (0.007 mole) of guanidine carbonate in 10 mL of N,N-dimethylacetamide, yielding 2,4-diamino-6-(3,5-dichlorophenyl)pteridine.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step B of Example 4

Sources & evidence

ORD record
ord-96fc163621c0450187a6f5517a5f7ecb
Source dataset
uspto-grants-1996_07
Patent number
US05532367

Reaction notes

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