Chloroformamidinium chloride → HCID 54399058, compound

HRID 1734160Notes

Reaction equation

HRID 1734160 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][C:5]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:4][N:3]=1.[ClH:22].Cl[C:24]([NH2:26])=[NH:25]>COCCOCCOC>[NH2:26][C:24]1[N:25]=[C:8]([NH2:9])[C:7]2[C:2](=[N:3][CH:4]=[C:5]([C:10]([Cl:22])=[CH:11][C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:14][CH:13]=3)[N:6]=2)[N:1]=1

Participants

4

Reactant 2

HCID 3084509Chloroformamidinium chlorideHCID 153352742-Amino-3-cyano-5-[(4-trifluoromethylphenyl)ethynyl]pyrazine

Product 1

HCID 54399058HCID 54399058, compound

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

This compound is prepared in a manner analogous to that of Step C of Example 7, using 2.9 grams (0.009 mole) of 2-amino-3-cyano-5-[(4-trifluoromethylphenyl)ethynyl]pyrazine and 0.9 gram (0.009 mole) of chloroformamidine hydrochloride in 20 mL of diglyme, yielding 2,4-diamino-6-[1 -chloro-2-(4-trifluoromethylphenyl)ethenyl]pteridine.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step C of Example 7

Sources & evidence

ORD record
ord-4d26024910c5498a9b9c907283df72f0
Source dataset
uspto-grants-1996_07
Patent number
US05532367

Reaction notes

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