N-Iodosuccinimide → 2-Amino-5-iodo-4-methylnicotinonitrile

HRID 1734210Notes

Reaction equation

HRID 1734210 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[CH:5]=[CH:4][N:3]=1.[I:11]N1C(=O)CCC1=O>CN(C)C=O>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[C:5]([I:11])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 103968872-Amino-4-methylpyridine-3-carbonitrile

Product 1

HCID 113912652-Amino-5-iodo-4-methylnicotinonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound is prepared in a manner analogous to that of Step C of Example 4, using 8.3 grams (0.063 mole) of 2-amino-3-cyano-4-methylpyridine (prepared as in Step B of Example 4) and 14.2 grams (0.063 mole) of N-iodosuccinimide in 250 mL of N,N-dimethylformamide, yielding 2-amino-3-cyano-5-iodo-4-methylpyridine.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step C of Example 4

Sources & evidence

ORD record
ord-ee009306dce64b2f888dfff5868bad91
Source dataset
uspto-grants-1996_07
Patent number
US05532370

Reaction notes

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