反应详情

The thus obtained compound (2) (5.1 g; 35.4 mmol) is dissolved in triethylamine (10.37 g; 103 mmol) and acetonitrile (127 ml), and methanesulfonyl chloride (8.13 g; 71 mmol) is dropwise added thereto under ice-cooling. The resultant mixture is ice-cooled for 1 hour and allowed to react at room temperature for 3 hours. The reaction mixture is washed with water, dried and concentrated, followed by addition of diethyl ether. Precipitated crystals are collected by filtration to give trans-1,2-bis(methanesulfonyloxymethyl)cyclohexane (3) (5.4 g).

1. temperatureunder ice-cooling
2. temperaturecooled for 1 hour
3. customto react at room temperature for 3 hours
4. washThe reaction mixture is washed with water
5. customdried
6. concentrationconcentrated
7. additionfollowed by addition of diethyl ether
8. customPrecipitated crystals
9. filtrationare collected by filtration