反应详情

To a mixture of lithium aluminum hydride (52.22 g; 1,374 mol) and tetrahydrofuran (500 ml), a solution of trans-1,2-cyclohexanedicarboxylic acid (5) (118.18 g; 0.687 mol) in tetrahydrofuran (2 liters) is dropwise added under reflux, and the resultant mixture is allowed to react under reflux for 3 hours. After completion of the reaction, the reaction mixture is cooled, and wet tetrahydrofuran and ether are dropwise added thereto, followed by filtration. The filtrate is concentrated under reduced pressure to give trans-1,2-bis(hydroxymethyl)cyclohexane (2) (71.86 g).

1. temperatureunder reflux
2. customto react
3. temperatureunder reflux for 3 hours
4. customAfter completion of the reaction
5. temperaturethe reaction mixture is cooled
6. filtrationfollowed by filtration
7. concentrationThe filtrate is concentrated under reduced pressure