5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone → 2-(N,N-dimethylamino)methyl-5-hydroxy-4-pyridone

HRID 1734254노트

반응식

HRID 1734254 반응식
C([O:8][C:9]1[C:10](=[O:19])[CH2:11][C:12]([CH2:15][N:16]([CH3:18])[CH3:17])=[N:13][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[CH3:18][N:16]([CH2:15][C:12]1[CH2:11][C:10](=[O:19])[C:9]([OH:8])=[CH:14][N:13]=1)[CH3:17]

참가 물질

4

반응물 1

HCID 677480495-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

생성물 1

HCID 677480632-(N,N-dimethylamino)methyl-5-hydroxy-4-pyridone수율 147.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

5-Benzyloxy-2-(N,N-dimethylamino) methyl-4-pyridone 1.0 g) in methanol (15 ml) was subjected to catalytic reduction with 10% palladium on activated carbon (200 mg) at atmospheric pressure. After removal of catalyst, the solution was concentrated under reduced pressure to give 2-(N,N-dimethylamino) methyl -5-hydroxy-4-pyridone (0.96 g).

후처리

  1. customAfter removal of catalyst
  2. concentrationthe solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d88c939e0f62467fb8cd38e914dacaa1
출처 데이터셋
uspto-grants-1996_07
특허 번호
US05532354

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