Hydrogen Bromide → HCID 14285592, compound
Reaction equation
[Br:1][C@@H:2]([P:6](=[O:11])([O:9]C)[O:7]C)[C@@H:3]([OH:5])[CH3:4].Br>>[Br:1][C@@H:2]([P:6](=[O:7])([OH:11])[OH:9])[C@@H:3]([OH:5])[CH3:4]Participants
3
Conditions
- Temperature
- 95 °C
Procedure
Following the method of Giordano, C, et al. [J. Org. Chem., 54, 1470(1989)], 100 mg of dimethyl (1R,2S)-1-bromo-2-hydroxypropylphosphonate were added to 1 ml of a 49% aqueous solution of hydrobromic acid, and the resulting mixture was stirred for 14 hours at 95° C. The solvent was distilled out of the reaction mixture to obtain (1R,2S)-1-bromo-2-hydroxypropylphosphonic acid in the form of a colorless oil. The result of analysis of the thus-obtained compound by 1H-NMP is described below.
Workup
- distillationThe solvent was distilled out of the reaction mixture
Sources & evidence
- ORD record
- ord-f3e51f9aaee045d7909449af8cb8af1c
- Source dataset
- uspto-grants-1996_07
- Patent number
- US05532402
Reaction notes
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