p-Toluenesulfonic acid → HCID 86587289, compound

HRID 1734406Notes

Reaction equation

HRID 1734406 reaction equation
[CH3:1][O:2][CH:3](OC)[CH2:4][C:5]([O:7][CH2:8][O:9][C:10](=[O:17])[CH2:11][CH:12](OC)[O:13][CH3:14])=[O:6].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH3:14][O:13][CH:12]=[CH:11][C:10]([O:9][CH2:8][O:7][C:5](=[O:6])[CH:4]=[CH:3][O:2][CH3:1])=[O:17]

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 86587290HCID 86587290, compound

Product 1

HCID 86587289HCID 86587289, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

Methylene di(3,3-dimethoxypropionate) prepared as described in Example 24 (14.01 g, 50 mmol) and a catalytic amount of p-toluene sulfonic acid is added to toluene (250 ml). The methanol is removed by warming the reaction under an N2 atmosphere. When the reaction is complete the toluene is distilled off under reduced pressure. Diethyl ether (250 ml) is added and the mixture is washed with saturated aqueous sodium hydrogen carbonate (5×50 ml) and water (3×50 ml). The organic layer is dried (MgSO4) before evaporation to give 8.52 g (79%) product.

Workup

  1. customThe methanol is removed
  2. temperatureby warming
  3. customthe reaction under an N2 atmosphere
  4. distillationis distilled off under reduced pressure
  5. additionDiethyl ether (250 ml) is added
  6. washthe mixture is washed with saturated aqueous sodium hydrogen carbonate (5×50 ml) and water (3×50 ml)
  7. dry with materialThe organic layer is dried (MgSO4)
  8. custombefore evaporation

Sources & evidence

ORD record
ord-6a507b1ea71e4343bf22d0914236f5cb
Source dataset
uspto-grants-1996_07
Patent number
US05534250

Reaction notes

Loading…