Hydrochloric Acid → HCID 135829371, compound

HRID 1734419Notes

Reaction equation

HRID 1734419 reaction equation
C1(C[O:5][C:6]2[C:7]3[C:11]([CH:12]=[CH:13][CH:14]=2)=[N:10][N:9]([CH3:15])[C:8]=3[S:16]([NH2:19])(=[O:18])=[O:17])CC1.Cl>C(O)(=O)C>[OH:5][C:6]1[C:7]2[C:11]([CH:12]=[CH:13][CH:14]=1)=[N:10][N:9]([CH3:15])[C:8]=2[S:16]([NH2:19])(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19083157HCID 19083157, compound

Product 1

HCID 135829371HCID 135829371, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture comprising 62 g (221 mmol) of 4-cyclopropylmethoxy-2-methyl-2H-indazole-3-sulfonamide, 120 ml of acetic acid and 120 ml of concentrated hydrochloric acid, was stirred at 80° C. for one hour. After concentrating acetic acid-hydrochloric acid, the mixture was poured into ice water. Crystals were collected by filtration and washed with water. Further, the crystals were washed with IPE and dried to obtain 35.1 g (yield: 70%) of the desired product. Melting point: 180°-181° C.

Workup

  1. concentrationAfter concentrating acetic acid-hydrochloric acid
  2. additionthe mixture was poured into ice water
  3. filtrationCrystals were collected by filtration
  4. washwashed with water
  5. washFurther, the crystals were washed with IPE
  6. customdried

Sources & evidence

ORD record
ord-ed15038539e24a9f8652fa849a4649ab
Source dataset
uspto-grants-1996_07
Patent number
US05534481

Reaction notes

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