反应详情

A mixture comprising 3 4 g of N1,N1 -dimethyl-N2 -([4-(2-fluoroethoxy)-2-methyl-2H-indazol-3-yl]sulfonyl}formamidine, 5 ml of concentrated hydrochloric acid and 50 ml of ethanol, was refluxed for 12 hours. Disappearance of the starting material was confirmed by TLC, and then ethanol was distilled off. Water was added to the residue, whereupon the formed crystals were collected by filtration and washed with water and IPE to obtain 2.4 g (yield: 85%) of the desired product. Melting point: 178°-180° C.

1. distillationethanol was distilled off
2. additionWater was added to the residue, whereupon the formed crystals
3. filtrationwere collected by filtration
4. washwashed with water and IPE