Trifluoroacetic acid → HCID 69834649, compound

HRID 1734511Notes

Reaction equation

HRID 1734511 reaction equation
[N+:1]([C:4]1[CH:29]=[CH:28][C:7]([CH2:8][O:9][C:10](=[O:27])[C@@H:11]2[CH2:15][CH2:14][CH2:13][N:12]2[C:16](=[O:26])[CH2:17][NH:18]C(OC(C)(C)C)=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>C(Cl)Cl>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[N+:1]([C:4]1[CH:29]=[CH:28][C:7]([CH2:8][O:9][C:10](=[O:27])[C@@H:11]2[CH2:15][CH2:14][CH2:13][N:12]2[C:16](=[O:26])[CH2:17][NH2:18])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 69836587HCID 69836587, compound

Product 1

HCID 69834649HCID 69834649, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4.10 g of Compound (22) obtained in the step (a) in 5 ml of methylene chloride was added 2.5 ml of trifluoroacetic acid under ice-cooling and the reaction mixture was stirred for 1 hour, then, 4 ml of trifluoroacetic acid was added to the reaction mixture and the stirring was continued for 2 hours. After reaction, the solvent was removed to give 5.82 g of glycyl-L-proline p-nitrobenzyl ester trifluoroacetic acid salt as pale brownish oil.

Workup

  1. temperaturecooling
  2. waitthe stirring was continued for 2 hours
  3. customAfter reaction
  4. customthe solvent was removed

Sources & evidence

ORD record
ord-c8c1541291f44fb5afef7444ff3927d7
Source dataset
uspto-grants-1996_07
Patent number
US05534510

Reaction notes

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