4-Piperidinecarboxylic acid → HCID 67734335, compound

HRID 1734514Notes

Reaction equation

HRID 1734514 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1)(=[O:12])[CH3:11].[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 37734-Piperidinecarboxylic acidHCID 7918Acetic Anhydride

Product 1

HCID 67734335HCID 67734335, compound

Procedure

1-acetylpiperidine-4-carboxylic acid 1-Acetylpiperidine-4-carboxylic acid is prepared by bringing a solution of piperidine-4-carboxylic acid in acetic anhydride to reflux for 2 hours and then stirring for 16 hours at room temperature. The solution is then concentrated and the residue is triturated in ether. The solid compound is recovered by filtration.

Workup

  1. temperatureto reflux for 2 hours
  2. concentrationThe solution is then concentrated
  3. customthe residue is triturated in ether
  4. filtrationThe solid compound is recovered by filtration

Sources & evidence

ORD record
ord-f616d1410c614487a26b58b9946a0739
Source dataset
uspto-grants-1996_07
Patent number
US05534517

Reaction notes

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