Bromine → 1-Benzyl-7-benzyloxy-3-bromo-2-methylpyrrolo[2,3-d]pyridazine

HRID 1734525Notes

Reaction equation

HRID 1734525 reaction equation
[CH2:1]([N:8]1[C:12]2=[C:13]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:14]=[N:15][CH:16]=[C:11]2[CH:10]=[C:9]1[CH3:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:26]Br>ClCCl>[CH2:1]([N:8]1[C:12]2=[C:13]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:14]=[N:15][CH:16]=[C:11]2[C:10]([Br:26])=[C:9]1[CH3:25])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 194377401-Benzyl-7-benzyloxy-2-methylpyrrolo[2,3-d]pyridazine

Product 1

HCID 194377641-Benzyl-7-benzyloxy-3-bromo-2-methylpyrrolo[2,3-d]pyridazineYield 85%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

42.3 g (0.128 mol) of 1-benzyl-7-benzyloxy-2-methylpyrrolo[2,3-d]pyridazine and 6.6 ml (0.128 mol) of bromine are reacted in a total of 200 ml of dichloromethane as described for Example 3a. Yield: 85%, m.p.: 122°-123° C.

Sources & evidence

ORD record
ord-f5c0238201ef4d11aa51d2f8109999e4
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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