Bromine → 1-Benzyl-3-bromo-7-chloro-2-methylpyrrolo[2,3-d]pyridazine

HRID 1734526Notes

Reaction equation

HRID 1734526 reaction equation
[CH2:1]([N:8]1[C:12]2=[C:13]([Cl:17])[N:14]=[N:15][CH:16]=[C:11]2[CH:10]=[C:9]1[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:19]Br>ClCCl>[CH2:1]([N:8]1[C:12]2=[C:13]([Cl:17])[N:14]=[N:15][CH:16]=[C:11]2[C:10]([Br:19])=[C:9]1[CH3:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 194377481-Benzyl-7-chloro-2-methylpyrrolo[2,3-d]pyridazine

Product 1

HCID 194377701-Benzyl-3-bromo-7-chloro-2-methylpyrrolo[2,3-d]pyridazineYield 83%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

8.0 g (31 mmol) of 1-benzyl-7-chloro-2-methylpyrrolo[2,3-d]pyridazine and 1.59 ml (31 mmol) of bromine are reacted in a total of 150 ml of dichloromethane as described for Example 3a. Yield: 83%, m.p.: 138°-140° C.

Sources & evidence

ORD record
ord-b7f7d0f3dbc24c5483e763f743a7d838
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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