HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 19437738, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Benzyl-7-(4-fluorobenzyloxy)-3-hydroxymethyl-2-methylpyrrolo[2,3-d]pyridazine | HCID 9951627 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19437738 | HCID 19437738 | 55% |
Reaction Steps
0.1 g (0.26 mmol) of 1-benzyl-7-(4-fluorobenzyloxy)-3-hydroxymethyl-2-methylpyrrolo [2,3-d]pyridazine, 0.164 g (0.8 mmol) of dicyclohexylcarbodiimide and 0.046 ml (0.8 mmol) of glacial acetic acid are reacted in 5 ml of anhydrous tetrahydrofuran as described for Example 7a. Yield: 55%, m.p.: 109°-110° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05534515 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-8542202a8a1a4c04914ec3c5f2368e55 |
| Source note | uspto-grants-1996_07 |