Phosphorus oxychloride → HCID 19437744, compound

HRID 1734538Notes

Reaction equation

HRID 1734538 reaction equation
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([CH2:7][N:8]2[C:12]3[C:13](=O)[NH:14][N:15]=[CH:16][C:11]=3[CH:10]=[C:9]2[CH3:18])=[CH:5][CH:4]=1.P(Cl)(Cl)([Cl:23])=O>>[Cl:23][C:13]1[N:14]=[N:15][CH:16]=[C:11]2[CH:10]=[C:9]([CH3:18])[N:8]([CH2:7][C:6]3[CH:19]=[CH:20][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[C:12]=12

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 19437758HCID 19437758, compound

Product 1

HCID 19437744HCID 19437744, compoundYield 76%

Procedure

17.8 g (66 mmol) of 1-(4-methoxybenzyl)-2-methyl-6,7-dihydropyrrolo[2,3-d]pyridazine-7-one are reacted at 100° C. for 2 h in 130 ml of phosphorus oxychloride. Purification: chromatography on silica gel (eluent: ethyl acetate). Yield: 76%. M.p.: 126°-128° C.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-dde5dd5296624b569fa4056d00424cc5
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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