Phosphorus oxychloride → HCID 19437771, compound

HRID 1734539Notes

Reaction equation

HRID 1734539 reaction equation
[CH2:1]([N:5]1[C:9]2[CH2:10][NH:11][N:12]=[CH:13][C:8]=2[CH:7]=[C:6]1[CH3:14])[CH:2]([CH3:4])[CH3:3].P(Cl)(Cl)([Cl:17])=O>>[Cl:17][C:10]1[N:11]=[N:12][CH:13]=[C:8]2[CH:7]=[C:6]([CH3:14])[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:9]=12

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 19437757HCID 19437757, compound

Product 1

HCID 19437771HCID 19437771, compoundYield 75%

Procedure

3.8 g (12 mmol) of 1-isobutyl-2-methyl-6,7-dihydropyrrolo[2,3-d]pyridazine are reacted at 100° C. for 2 h in 30 ml of phosphorus oxychloride. Purification: chromatography on silica gel (eluent: toluene/dioxane=2:1). Yield: 75%. M.p.: 96°-99° C.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-e48478e986ba425583895dff5839998e
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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