Triethylamine → HCID 19437758, compound

HRID 1734540Notes

Reaction equation

HRID 1734540 reaction equation
C([O:8][C:9]1[N:10]=[N:11][C:12](Cl)=[C:13]2[CH:17]=[C:16]([CH3:18])[N:15]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C:14]=12)C1C=CC=CC=1.C(N(CC)CC)C.[H][H]>[Pd].CO>[CH3:27][O:26][C:23]1[CH:22]=[CH:21][C:20]([CH2:19][N:15]2[C:14]3[C:9](=[O:8])[NH:10][N:11]=[CH:12][C:13]=3[CH:17]=[C:16]2[CH3:18])=[CH:25][CH:24]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 19437761HCID 19437761, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19437758HCID 19437758, compoundYield 69%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

38.3 g (97 mmol) of 7-benzyloxy-4-chloro-1-(4-methoxybenzyl)-2-methylpyrrolo[2,3-d]pyridazine (contaminated with about 5% of the isomeric 4-benzyloxy compound), 15 ml of triethylamine and 3.0 g of palladium (5%)/carbon catalyst are hydrogenated with hydrogen for 10 h in 3 1 of methanol. Purification: crystallization from methanol. Yield: 69%, m.p.: 212°-213° C.

Workup

  1. customPurification
  2. customcrystallization from methanol

Sources & evidence

ORD record
ord-2bd0f55025c64decb8b8898b70564e99
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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