Triethylamine → HCID 19437765, compound

HRID 1734541Notes

Reaction equation

HRID 1734541 reaction equation
C([O:8][C:9]1[N:10]=[N:11][C:12](Cl)=[C:13]2[CH:17]=[C:16]([CH3:18])[N:15]([CH2:19][CH:20]([CH3:22])[CH3:21])[C:14]=12)C1C=CC=CC=1.C(N(CC)CC)C.[H][H]>CO.[Pd]>[CH2:19]([N:15]1[C:14]2[C:9](=[O:8])[NH:10][N:11]=[CH:12][C:13]=2[CH:17]=[C:16]1[CH3:18])[CH:20]([CH3:22])[CH3:21]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 19437778HCID 19437778, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19437765HCID 19437765, compoundYield 52%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4.5 g (13.6 mmol) of 7-benzyloxy-4-chloro-1-isobutyl-2-methylpyrrolo[2,3-d]pyridazine (contaminated with about 40% of the isomeric 4-benzyloxy compound), 4 ml of triethylamine and 0.5 g of palladium (5%)/carbon catalyst are hydrogenated with hydrogen for 5 h in 500 ml of methanol. Purification: chromatography on silica gel (eluent: toluene/dioxane 4:1). Yield: 52%, m.p.: 188°-191° C.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-e15313ae45bd40a7b390a72000a452fe
Source dataset
uspto-grants-1996_07
Patent number
US05534515

Reaction notes

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