Acetic Anhydride → HCID 15291737, compound

Participants

Reaction Steps

4-aminomethyl-4-hydroxy-1-methylpiperidine (2.95 g, 0.02 mole), potassium carbonate (6.5 g, 0.047 mole) and acetic anhydride (8.5 g, 0.08 mole) in methanol were mixed at room temperature for two hours. Sodium hydroxide was added for neutralization and the solution extracted with chloroform. After evaporation, a yellow oil was obtained which was identified as 4-acetamidomethyl-4-hydroxy--1-methylpiperidine (3.4 g, 0.018 mole, 91% yield).

Provenance & Evidence