反应详情

4-aminomethyl-4-hydroxy-1-methylpiperidine (2.95 g, 0.02 mole), potassium carbonate (6.5 g, 0.047 mole) and acetic anhydride (8.5 g, 0.08 mole) in methanol were mixed at room temperature for two hours. Sodium hydroxide was added for neutralization and the solution extracted with chloroform. After evaporation, a yellow oil was obtained which was identified as 4-acetamidomethyl-4-hydroxy--1-methylpiperidine (3.4 g, 0.018 mole, 91% yield).

1. extractionthe solution extracted with chloroform
2. customAfter evaporation
3. customa yellow oil was obtained which