Acetic Anhydride → HCID 15291737, compound

HRID 1734561Notes

Reaction equation

HRID 1734561 reaction equation
[NH2:1][CH2:2][C:3]1([OH:10])[CH2:8][CH2:7][N:6]([CH3:9])[CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].[C:17](OC(=O)C)(=[O:19])[CH3:18].[OH-].[Na+]>CO>[C:17]([NH:1][CH2:2][C:3]1([OH:10])[CH2:8][CH2:7][N:6]([CH3:9])[CH2:5][CH2:4]1)(=[O:19])[CH3:18]

Participants

6

Reactant 4

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 64842624-(Aminomethyl)-1-methylpiperidin-4-ol

Product 1

HCID 15291737HCID 15291737, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-aminomethyl-4-hydroxy-1-methylpiperidine (2.95 g, 0.02 mole), potassium carbonate (6.5 g, 0.047 mole) and acetic anhydride (8.5 g, 0.08 mole) in methanol were mixed at room temperature for two hours. Sodium hydroxide was added for neutralization and the solution extracted with chloroform. After evaporation, a yellow oil was obtained which was identified as 4-acetamidomethyl-4-hydroxy--1-methylpiperidine (3.4 g, 0.018 mole, 91% yield).

Workup

  1. extractionthe solution extracted with chloroform
  2. customAfter evaporation
  3. customa yellow oil was obtained which

Sources & evidence

ORD record
ord-754de210565146cdaccae396e19092bf
Source dataset
uspto-grants-1996_07
Patent number
US05534520

Reaction notes

Loading…