反应详情

4-acetamidomethyl-4-hydroxy-1-methylpiperidine (3.4 g, 0.018 mole) in dry THF was refluxed in the presence of lithium aluminium hydride (4 g). After 3 days, the mixture was poured into an ice-water bath and filtered through Celite. The solvent was evaporated and after addition of water the solution was extracted with chloroform, and the extract was dried with magnesium sulfate and evaporated to yield 1.03 g (33% yield) crude material. The product thus obtained, 4-ethylaminomethyl-4-hydroxy-1-methylpiperidine, was used without further purification.

1. additionthe mixture was poured into an ice-water bath
2. filtrationfiltered through Celite
3. customThe solvent was evaporated
4. additionafter addition of water the solution
5. extractionwas extracted with chloroform
6. dry with materialthe extract was dried with magnesium sulfate
7. customevaporated