1-Propanol → HCID 86748566, compound

A mixture of (±)-cis-[4-(4,5-dichloro-2-nitroanilino)-2-cyclopenten-1-yl]methanol (5.00 g, 16.5 mmol) and Raney nickel (Aldrich, slurry in water, 500 mg wet) in n-propanol (250 mL) was shaken under hydrogen (50 psi) on a Parr shaker for 2 hours. The catalyst was filtered off, solvent evaporated in vacuo, and the residue dissolved in triethylorthoformate(300 mL)-methanesulfonic acid (200 mg). After 18 hours, the solution was concentrated to a syrup which was dissolved in 1N hydrochloric acid (40 mL) and stirred at ambient temperature overnight. The pH was adjusted to 7 with 1N sodium hydroxide and the solution extracted with chloroform (3×50 mL). The contents of the dried (sodium sulfate) chloroform solution was chromatographed on silica gel. Title compound was eluted with 5% methanol-chloroform as a colorless oil which solidified from ethyl acetate-hexanes to give white powder (3.98 g, 85%). m.p. 142°-145° C.; 1H-NMR(DMSO-d6) and mass spectrum(CI) consistent with structure.

1. filtrationThe catalyst was filtered off
2. customsolvent evaporated in vacuo
3. dissolutionthe residue dissolved in triethylorthoformate(300 mL)-methanesulfonic acid (200 mg)
4. waitAfter 18 hours
5. concentrationthe solution was concentrated to a syrup which
6. dissolutionwas dissolved in 1N hydrochloric acid (40 mL)
7. stirringstirred at ambient temperature overnight
8. extractionthe solution extracted with chloroform (3×50 mL)
9. dry with materialThe contents of the dried (sodium sulfate) chloroform solution
10. customwas chromatographed on silica gel
11. washTitle compound was eluted with 5% methanol-chloroform as a colorless oil which

ORD record

ord-f02b8e7c11c74301808eb6e460a3a037

Source dataset

uspto-grants-1996_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05534535