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HRID17347

反应详情

EQUATION

反应方程式

HRID 17347 的结构方程式

REACTANTS

反应物

2
结构：Cc1ccc(S(=O)(=O)O)cc1.O
HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

结构：Cc1c(C#N)c(NC(=O)COCc2ccccc2)c(O)c(F)c1-c1ccccc1
HCID86630838

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(-c2ccccc2)c(F)c2oc(COCc3ccccc3)nc2c1C#N
HCID68586913

未命名化合物

PROCEDURE

实验过程

Similarly, 2-(benzyloxy)-N-(3-cyano-6-fluoro-5-hydroxy-2-methyl[1,1′-biphenyl]-4-yl)acetamide (I-89) (418 mg, 1.07 mmol) was dissolve din toluene (8.4 ml), p-toluenesulfonic acid monohydrate (84 mg, 20 wt. %) was added, followed by heating under reflux for 18 hours.

WORKUP

后处理

  1. additionwas added
  2. temperatureby heating
  3. temperatureunder reflux for 18 hours