Hydrochloric Acid → HCID 19966035, compound

HRID 1734859Notes

Reaction equation

HRID 1734859 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([S:17][CH3:18])[C:12]=2[NH:19][C:20](=[O:36])[CH2:21][CH:22]2[C:35]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[O:29][C:28]3[C:23]2=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:37]>CO.C(Cl)Cl>[ClH:37].[N:1]1([CH2:6][CH2:7][CH2:8][O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([S:17][CH3:18])[C:12]=2[NH:19][C:20](=[O:36])[CH2:21][CH:22]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:28]=3[O:29][C:30]3[C:35]2=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19965983HCID 19965983, compound

Product 1

HCID 19966035HCID 19966035, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

100 mg of N-{2-[3-(1-imidazolyl)propoxy]methyl-6-methylthiophenyl}-2-(9H-xanthen-9-yl)acetamide (prepared as described in Example 1) were dissolved in a mixture of methanol and methylene chloride. An excess of concentrated aqueous hydrochloric acid was added to the solution, and then the solvent was removed by distillation under reduced pressure. The resulting residue was dissolved in methanol, and diethyl ether was added to produce 85 mg of the title compound as crystals, melting at 175°-184° C.

Workup

  1. customthe solvent was removed by distillation under reduced pressure
  2. dissolutionThe resulting residue was dissolved in methanol
  3. additiondiethyl ether was added

Sources & evidence

ORD record
ord-bcd7db09aa0f4ccbab7eae47c55355d8
Source dataset
uspto-grants-1996_07
Patent number
US05534529

Reaction notes

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