N,N-Dimethylglycine hydrochloride → HCID 53852169, compound

HRID 1734879Notes

Reaction equation

HRID 1734879 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C@H:13]([OH:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:7][C:6]=1[NH:22][C:23](=[O:39])[CH2:24][CH:25]1[C:38]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[O:32][C:31]2[C:26]1=[CH:27][CH:28]=[CH:29][CH:30]=2)([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:41][N:42]([CH3:47])[CH2:43][C:44](O)=[O:45]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C@H:13]([O:21][C:44](=[O:45])[CH2:43][N:42]([CH3:47])[CH3:41])[CH2:14][CH:15]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]2)=[CH:7][C:6]=1[NH:22][C:23](=[O:39])[CH2:24][CH:25]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:31]=2[O:32][C:33]2[C:38]1=[CH:37][CH:36]=[CH:35][CH:34]=2)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 75605N,N-Dimethylglycine hydrochlorideHCID 53722639HCID 53722639, compound

Product 1

HCID 53852169HCID 53852169, compound

Procedure

Following a procedure similar to that described in Preparation 25, but using (S)-N-[2-t-butyl-5-(4-cyclohexyl-3-hydroxybutyl)phenyl]-2-(9H-xanthen-9-yl)acetamide (prepared as described in Example 102) and N,N-dimethylglycine hydrochloride as starting materials, in relative proportions similar to those used in that Preparation, the title compound was obtained as a foam-like material.

Workup

  1. customthat described in Preparation 25
  2. customin relative proportions similar to those used in that Preparation

Sources & evidence

ORD record
ord-e57baab37abc4da099ab1b37c236125a
Source dataset
uspto-grants-1996_07
Patent number
US05534529

Reaction notes

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