Sodium Carbonate → HCID 19966001, compound

HRID 1734913Notes

Reaction equation

HRID 1734913 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH:12]([C:15]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23][CH3:24])[C:16]=1[NH2:17])([CH3:14])[CH3:13].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[CH:12]([C:15]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:24])=[O:9])[C:16]=1[NH2:17])([CH3:14])[CH3:13]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 70297m-Chloroperbenzoic acidHCID 10932356Benzenamine, 2-(1-methylethyl)-6-[(methylthio)methyl]-

Product 1

HCID 19966001HCID 19966001, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

12.9 g (52.3 mmol) of m-chloroperbenzoic acid (70% purity) were added over a period of 15 minutes to a suspension of 10.21 g (52.3 mmol) of 2-isopropyl-6-methylthiomethylaniline [prepared as described in step (i) above] and 5.31 g (50 mmol) of sodium carbonate in 200 ml of methylene chloride, whilst ice-cooling. The reaction mixture was stirred for 1.5 hours at the same temperature, after which it was diluted with methylene chloride, and the diluted mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate, with an aqueous solution of sodium sulfite and with water, in that order. The solvent was then removed by distillation under reduced pressure, and the resulting residue was recrystallized from a mixture of diethyl ether and diisopropyl ether, to give 7.74 g of the title compound as a first crop. The mother liquor was then concentrated by evaporation under reduced pressure, and the concentrate was repeatedly recrystallized from the same solvent to give a further 0.75 g of the title S-oxide derivative. The total yield was 8.49 g (yield 77%). The title compound melted at 91°-91.5° (after recrystallisation from a mixture of methylene chloride and diisopropyl ether).

Workup

  1. temperaturecooling
  2. washthe diluted mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate, with an aqueous solution of sodium sulfite and with water, in that order
  3. customThe solvent was then removed by distillation under reduced pressure
  4. customthe resulting residue was recrystallized from a mixture of diethyl ether and diisopropyl ether

Sources & evidence

ORD record
ord-b66442ed65884f6ead52a3005a4622d5
Source dataset
uspto-grants-1996_07
Patent number
US05534529

Reaction notes

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