Nitric Acid → HCID 19436799, compound

HRID 1735010Notes

Reaction equation

HRID 1735010 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[N:14]([CH3:15])[N:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:6]=[N:7][CH:8]=1.[N+:20]([O-])([OH:22])=[O:21].S(=O)(=O)(O)O.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O:9][C:10]2[N:14]([CH3:15])[N:13]=[C:12]([C:16]([F:19])([F:17])[F:18])[C:11]=2[N+:20]([O-:22])=[O:21])[N:6]=[N:7][CH:8]=1

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 19436789HCID 19436789, compound

Product 1

HCID 19436799HCID 19436799, compoundYield 99%

Procedure

5-Methoxy-3-[[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (Compound No. 5, 1.2 g, 0.0043 mole) was added to a mixture of nitric acid (5 mL) and sulfuric acid (13 mL), and the mixture was stirred at room temperature for 18 hours. The reaction mixture was poured into ice and neutralized with 10% sodium hydroxide. Filtration gave, after drying, 5-methoxy-3-[[1-methyl-4-nitro-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (1.36 g, 99% yield) as a beige solid.

Workup

  1. filtrationFiltration
  2. customgave
  3. customafter drying

Sources & evidence

ORD record
ord-7cf123965f1442e6a758d15a1866a81c
Source dataset
uspto-grants-1996_07
Patent number
US05536701

Reaction notes

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