Nitric Acid → HCID 19436799, compound

Participants

Reaction Steps

5-Methoxy-3-[[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (Compound No. 5, 1.2 g, 0.0043 mole) was added to a mixture of nitric acid (5 mL) and sulfuric acid (13 mL), and the mixture was stirred at room temperature for 18 hours. The reaction mixture was poured into ice and neutralized with 10% sodium hydroxide. Filtration gave, after drying, 5-methoxy-3-[[1-methyl-4-nitro-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy]pyridazine (1.36 g, 99% yield) as a beige solid.

Provenance & Evidence