1-Methylpiperazine → HCID 19068940, compound

HRID 1735092Notes

Reaction equation

HRID 1735092 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]2[CH:11]=[C:12]([C:14](Cl)=[O:15])[S:13][C:3]1=2.[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]2[CH:11]=[C:12]([C:14]([N:21]3[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]3)=[O:15])[S:13][C:3]1=2

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 19068976HCID 19068976, compound

Product 1

HCID 19068940HCID 19068940, compoundYield 64.7%

Procedure

Preparation as for (30) from (26) (0.96 g) and N-methylpiperazine (0.46 g), stirring for 14 days, rinse up on silica gel column using dichloromethane/methanol (9/1) as eluent. Precipitation as the oxalate salt gave (31) (0.78 g), m.p. 219.1°-219.5° C.

Workup

  1. washrinse up on silica gel column
  2. customPrecipitation as the oxalate salt

Sources & evidence

ORD record
ord-319e1588d35243b4b93e2682a608901d
Source dataset
uspto-grants-1996_07
Patent number
US05536721

Reaction notes

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