Hydrochloric Acid → HCID 19068952, compound

HRID 1735103Notes

Reaction equation

HRID 1735103 reaction equation
[OH-].[K+].[Cl:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8]1[S:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:7]2=1.Cl>C(OCC)(=O)C.C1(C)C=CC=CC=1>[Cl:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH3:13])[C:8]1[S:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:7]2=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19068973HCID 19068973, compound

Product 1

HCID 19068952HCID 19068952, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 21584019Toluene ethylacetateSolvent

Procedure

KOH (0.57 g) was dissolved in methanol-water (1/1) (10 ml). (49) (0.50 g) was added and the mixture refluxed for 13/4 h. After cooling the mixture was acidified with 1M HCl to pH=1. The precipitate was filtered off, washed with water and dried to give 0.44 g (93%) of (54). M.p. 259°-262° C.

Workup

  1. temperaturethe mixture refluxed for 13/4 h
  2. temperatureAfter cooling the mixture
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-71162070c58943ddaf2f435c8bedfe1f
Source dataset
uspto-grants-1996_07
Patent number
US05536721

Reaction notes

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