HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-Chloro-1-methyl-5-nitroindole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-chloro-5-nitro-1H-indole-3-carbaldehyde | HCID 3809201 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-1-methyl-5-nitroindole-3-carbaldehyde | HCID 10823874 | — |
Reaction Steps
To 5 g of (65) in 100 ml THF was added 550 mg NaH and 2.5 ml methyliodide. The reaction was left with stirring overnight. Most of the THF was evaporated off, water was added, and the water phase extracted with EtOAc. The water phase was then acidified with acetic acid, which precipitated the pure product. Filtration and drying gave 770 mg of (66).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05536721 |
| Source dataset | uspto-grants-1996_07 |
| ORD ID | ord-31f63e112e3f425db993048849140007 |
| Source note | uspto-grants-1996_07 |