反应详情

To 5 g of (65) in 100 ml THF was added 550 mg NaH and 2.5 ml methyliodide. The reaction was left with stirring overnight. Most of the THF was evaporated off, water was added, and the water phase extracted with EtOAc. The water phase was then acidified with acetic acid, which precipitated the pure product. Filtration and drying gave 770 mg of (66).

1. waitThe reaction was left
2. customMost of the THF was evaporated off
3. additionwater was added
4. extractionthe water phase extracted with EtOAc
5. customprecipitated the pure product
6. filtrationFiltration
7. customdrying