Acetic Acid → HCID 23208281, compound

HRID 1735136Notes

Reaction equation

HRID 1735136 reaction equation
Br.[Br:2][CH2:3][C:4]1[CH:15]=[N:14][C:7]2[N:8]=[C:9]([NH2:13])[N:10]=[C:11]([NH2:12])[C:6]=2[CH:5]=1.CCO[CH2:19][CH3:20].[CH3:21]C(O)=O>>[Br:2][CH2:3][C:4]1[CH:15]=[N:14][C:7]2[N:8]=[C:9]([NH2:13])[N:10]=[C:11]([NH2:12])[C:6]=2[C:5]=1[CH2:21][CH2:19][CH3:20]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 105628616-(Bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine

Product 1

HCID 23208281HCID 23208281, compound

Procedure

The hydroxymethyl compound 2,4-diamino-5-propylpyrido[2,3-d]pyrimidine-6-methanol (III-1) was treated with dry HBr in AcOH as reported for 6-(bromomethyl)-2,4-diaminopyrido [2,3-d]pyrimidine (III-2, where R1 is H). Addition of Et2O caused precipitation of yellow solid which was collected with the aid of Et2O and dried in vacuo to afford the HBr salt of the product (III-3).

Workup

  1. customprecipitation of yellow solid which
  2. customwas collected with the aid of Et2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-77cdc560503846098bb27ca0f863aa64
Source dataset
uspto-grants-1996_07
Patent number
US05536724

Reaction notes

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