Pyridine → HCID 15838313, compound

HRID 1735151Notes

Reaction equation

HRID 1735151 reaction equation
Cl.[NH2:2][C:3]1[CH:30]=[CH:29][C:6]([O:7][C@H:8]2[CH2:13][CH2:12][C@H:11]3[C@H:14]4[C@H:24]([CH2:25][CH2:26][C@:9]23[CH3:10])[C@:22]2([CH3:23])[C@H:17]([N:18]([CH3:28])[C:19](=[O:27])[CH2:20][CH2:21]2)[CH2:16][CH2:15]4)=[CH:5][CH:4]=1.[C:31](OC(=O)C)(=[O:33])[CH3:32].N1C=CC=CC=1>C(Cl)Cl>[C:31]([NH:2][C:3]1[CH:4]=[CH:5][C:6]([O:7][C@H:8]2[CH2:13][CH2:12][C@H:11]3[C@H:14]4[C@H:24]([CH2:25][CH2:26][C@:9]23[CH3:10])[C@:22]2([CH3:23])[C@H:17]([N:18]([CH3:28])[C:19](=[O:27])[CH2:20][CH2:21]2)[CH2:16][CH2:15]4)=[CH:29][CH:30]=1)(=[O:33])[CH3:32]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 22862485HCID 22862485, compound

Product 1

HCID 15838313HCID 15838313, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 17β-(4-aminophenoxy)-4-methyl-5α-4-azaandrostan-3-one hydrochloride (7mg) in CH2Cl2 (100 μl) was added acetic anhydride (30 μl) followed by adding pyridine (50 μl). The mixture was stirred at room temperature for 2 hr and then concentrated to dryness. The residue was purified via a silica gel plate developed with 5% MeOH--EtOAc (Rf =0.3) to give the title product, mp. 340° C.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was purified via a silica gel plate

Sources & evidence

ORD record
ord-2f498b010a8649c4ace2bbae778faeb6
Source dataset
uspto-grants-1996_07
Patent number
US05536727

Reaction notes

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