Hydrazine hydrate (1:1) → HCID 15838328, compound

HRID 1735156Notes

Reaction equation

HRID 1735156 reaction equation
[CH2:1]([O:3][C:4](=[O:35])[CH2:5][O:6][C@H:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:23]([CH2:24][CH2:25][C@:8]12[CH3:9])[C@:21]1([CH3:22])[C:16]([N:17](C(=O)C2C=CC=CC=2)[C:18](=[O:26])[CH2:19][CH2:20]1)=[CH:15][CH2:14]3)[CH3:2].O.NN>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:35])[CH2:5][O:6][C@H:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:23]([CH2:24][CH2:25][C@:8]12[CH3:9])[C@:21]1([CH3:22])[C:16]([NH:17][C:18](=[O:26])[CH2:19][CH2:20]1)=[CH:15][CH2:14]3)[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 15838327HCID 15838327, compound

Product 1

HCID 15838328HCID 15838328, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the product of Step C, above, (90 mg) in CH2Cl2 (2.0 ml) was added hydrazine hydrate (0.2 ml). The mixture was shaken for a few minutes and purified via preparative TLC using two silica gel plates (1500μ) developed with EtOAc to give the title product (Rf =0.54).

Workup

  1. custompurified via preparative TLC

Sources & evidence

ORD record
ord-2a5f71db80264ba5b1d38ec9cb3e9a27
Source dataset
uspto-grants-1996_07
Patent number
US05536727

Reaction notes

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