HCID 15838328, compound → HCID 86749639, compound

HRID 1735157Notes

Reaction equation

HRID 1735157 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][O:6][C@H:7]1[CH2:12][CH2:11][C@H:10]2[C@H:13]3[C@H:23]([CH2:24][CH2:25][C@:8]12[CH3:9])[C@:21]1([CH3:22])[C:16]([NH:17][C:18](=O)[CH2:19][CH2:20]1)=[CH:15][CH2:14]3)[CH3:2]>C(O)(=O)C.[Pt]=O>[CH3:9][C@:8]12[CH2:25][CH2:24][C@H:23]3[C@@H:13]([CH2:14][CH2:15][C@@H:16]4[C@:21]3([CH3:22])[CH2:20][CH2:19][CH:18]=[N:17]4)[C@@H:10]1[CH2:11][CH2:12][C@@H:7]2[O:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:27]

Participants

4

Reactant 1

HCID 15838328HCID 15838328, compound

Product 1

HCID 86749639HCID 86749639, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

The product of Step D, above, and platinum oxide (35 mg) in glacial acetic acid (2 ml) was hydrogenated at 40 psi for 22.5 hours. The mixture was filtered through a pad,of celite. The filtrate was concentrated and the residue purified via preparative TLC using one silica gel plate (1000μ) developed with EtOAc to give the title product (Rf =0.22; mp 170°-172° C.).

Workup

  1. filtrationThe mixture was filtered through a pad,of celite
  2. concentrationThe filtrate was concentrated
  3. customthe residue purified via preparative TLC

Sources & evidence

ORD record
ord-15f21067f0d44734b39807170b0d8cda
Source dataset
uspto-grants-1996_07
Patent number
US05536727

Reaction notes

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