Diisopropylethylamine → HCID 18917489, compound

HRID 1735257Notes

Reaction equation

HRID 1735257 reaction equation
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([N:8]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH2:12][N:11]3[CH:19]=[CH:20][CH:21]=[C:10]3[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.C(N(CC)C(C)C)(C)C.[Cl:33][C:34]1[C:39]([C:40](Cl)=[O:41])=[CH:38][CH:37]=[CH:36][N:35]=1>C(Cl)Cl>[CH:21]1[CH:20]=[CH:19][N:11]2[CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:8]([C:6]([C:5]3[CH:22]=[CH:23][C:2]([NH:1][C:40]([C:39]4[C:34]([Cl:33])=[N:35][CH:36]=[CH:37][CH:38]=4)=[O:41])=[CH:3][CH:4]=3)=[O:7])[CH2:9][C:10]=12

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27745412-Chloronicotinoyl chlorideHCID 1082828010,11-dihydro-10(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Product 1

HCID 18917489HCID 18917489, compoundYield 79.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 6.06 g of 10, 11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2, 1-c][1,4]benzodiazepine and 10 ml of N,N-diisopropylethylamine is added a solution of 4.0 g of 2-chloropyridine-3-carbonyl chloride in 25 ml of methylene chloride. The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is quenched with water and the organic layer washed well with water. The organic layer is dried, filtered and evaporated in vacuo to a pale yellow product which is crystallized from 1:1 ethyl acetate:hexane to give 7.0 g of the desired product; M+ =442.

Workup

  1. customThe reaction mixture is quenched with water
  2. washthe organic layer washed well with water
  3. customThe organic layer is dried
  4. filtrationfiltered
  5. customevaporated in vacuo to a pale yellow product which
  6. customis crystallized from 1:1 ethyl acetate

Sources & evidence

ORD record
ord-d9585bfb395a4ba48d87b2c34d947c19
Source dataset
uspto-grants-1996_07
Patent number
US05536718

Reaction notes

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