4-(2,3-Dihydro-2,2-dimethylbenzofuran-7-ylmethyl)cyclohexanone → 2,4-Diamino-6-(2,3-dihydro-2,2-dimethylbenzofuran-7-ylmethyl)-5,6,7,8-tetrahydroquinazoline

HRID 1735305Notes

Reaction equation

HRID 1735305 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][CH:12]3[CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]3)[C:4]=2[O:3]1.[C:20]([NH:22][C:23]([NH2:25])=[NH:24])#[N:21]>C(OCCOCCO)C>[NH2:25][C:23]1[N:22]=[C:20]([NH2:21])[C:16]2[CH2:17][CH:12]([CH2:11][C:10]3[C:4]4[O:3][C:2]([CH3:19])([CH3:1])[CH2:6][C:5]=4[CH:7]=[CH:8][CH:9]=3)[CH2:13][CH2:14][C:15]=2[N:24]=1

Participants

4

Reactant 2

HCID 197052604-(2,3-Dihydro-2,2-dimethylbenzofuran-7-ylmethyl)cyclohexanoneHCID 178418324HCID 178418324, compound

Product 1

HCID 197052122,4-Diamino-6-(2,3-dihydro-2,2-dimethylbenzofuran-7-ylmethyl)-5,6,7,8-tetrahydroquinazoline

Reagents, catalysts & solvents 1

HCID 8146Diethylene Glycol Monoethyl EtherSolvent

Procedure

This compound is prepared in a manner analogous to that of Example 1, using 3.4 grams (0.013 mole) of 4-(2,3-dihydro-2,2-dimethylbenzofuran- 7-ylmethyl)cyclohexanone and 1.2 grams (0.014 mole) of cyanoguanidine in 2-(2-ethoxyethoxy)ethanol, yielding 2,4-diamino-6-(2,3-dihydro-2,2-dimethylbenzofuran-7-ylmethyl)-5,6,7,8-tetrahydroquinazoline.

Workup

  1. customThis compound is prepared in a manner analogous to that of Example 1

Sources & evidence

ORD record
ord-f89a92292b8e4d51b77ccd043b70c173
Source dataset
uspto-grants-1996_07
Patent number
US05536725

Reaction notes

Loading…