Ammonium Chloride → HCID 19705215, compound

HRID 1735344Notes

Reaction equation

HRID 1735344 reaction equation
[CH3:1][Li].[C:3]1([CH:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH:11]=[CH:10]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl-].[NH4+]>C(OCC)C.O.[Cu]Br>[CH3:1][CH:10]1[CH:9]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH2:14][CH2:13][C:12](=[O:15])[CH2:11]1

Participants

7

Reactant 3

HCID 25517Ammonium ChlorideHCID 110628762-Cyclohexen-1-one, 4-phenyl-HCID 178418348HCID 178418348, compound

Product 1

HCID 19705215HCID 19705215, compoundYield 37.4%

Reagents, catalysts & solvents 3

HCID 24593copper(I) bromideCatalystHCID 962WaterSolventHCID 3283Diethyl EtherSolvent4×

Conditions

Temperature
-20 °C

Procedure

Under a nitrogen atmosphere, a stirred mixture of 2.9 grams (0.020 mole) of copper(I) bromide in 10 mL of diethyl ether was cooled to -20° C., and 50 mL (0.070 mole) of 1.4M methyllithium in diethyl ether was added slowly. Upon completion of addition, a solution of 4.6 grams (0.027 mole) of 4-phenyl-2-cyclohexenone in 5 mL of diethyl ether was added dropwise at a rate to maintain the reaction mixture temperature below -20° C. Upon completion of addition, a solution of 4.2 grams (0.080 mole) of ammonium chloride in 20 mL of water was added. Upon completion of addition, the reaction mixture was stirred as it warmed to ambient temperature. The reaction mixture was then diluted with 200 mL of diethyl ether and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was subjected to column chromatography on silica gel. Elution was accomplished commencing with 10% diethyl ether in petroleum ether and finishing with 15% diethyl ether in petroleum ether. The product-containing fractions were combined and concentrated under reduced pressure, yielding 1.9 grams of 3-methyl-4-phenylcyclohexanone as a liquid. The NMR spectrum was consistent with the proposed structure, and it indicated that the product was predominantly the trans isomer. The reaction was repeated on a larger scale. The 3-methyl-4-phenylcyclohexanone isolated from the larger reaction was a solid, mp 71.5°-72.5° C. The NMR spectrum of a sample from the larger reaction was also consistent with the proposed structure.

Workup

  1. additionUpon completion of addition
  2. temperatureto maintain the reaction mixture temperature below -20° C
  3. additionUpon completion of addition
  4. additionUpon completion of addition
  5. temperaturewarmed to ambient temperature
  6. filtrationfiltered
  7. concentrationThe filtrate was concentrated under reduced pressure to a residue
  8. washElution
  9. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5c18ff0b99aa4fd7a157c949eceb7496
Source dataset
uspto-grants-1996_07
Patent number
US05536725

Reaction notes

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