反应详情

温度

180 °C

A suspension of 1.6 grams (0.005 mole) of 4-amino-2-methylsulfinyl-6-(2-chlorophenyl)-5,6,7,8-tetrahydroquinazoline (prepared as in Example 17) and 10 mL of aqueous 40% methylamine in 50 mL of ethanol is placed in a glass tube, which is then sealed. The sealed tube is heated at about 180° C. for 7 hours and then is cooled in an ice-bath and opened. The reaction mixture is concentrated under reduced pressure to a residue. The residue is stirred with an aqueous 10% potassium carbonate solution, and the resultant suspension is extracted with chloroform. The extract is dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure to a residue. The residue is subjected to column chromatography on silica gel, yielding 4-amino-2-methylamino-6-(2-chlorophenyl)-5,6,7,8-tetrahydroquinazoline.

1. customis placed in a glass tube
2. customwhich is then sealed
3. temperatureis cooled in an ice-bath
4. concentrationThe reaction mixture is concentrated under reduced pressure to a residue
5. extractionthe resultant suspension is extracted with chloroform
6. dry with materialThe extract is dried with magnesium sulfate
7. filtrationfiltered
8. concentrationThe filtrate is concentrated under reduced pressure to a residue