HCID 178447866, compound → HCID 178447867, compound

HRID 1735370Notes

Reaction equation

HRID 1735370 reaction equation
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]=[CH:17][C:18]([OH:20])=[O:19])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)[CH2:2][CH3:3]>C(OCC)(=O)C.[Pd]>[CH2:1]([C@H:4]1[CH2:5][CH2:6][C@H:7]([C:10]2[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:14][CH:15]=2)[CH2:8][CH2:9]1)[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 178447866HCID 178447866, compound

Product 1

HCID 178447867HCID 178447867, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 12.6 g of 3-[4-(trans-4-propylcyclohexyl)-phenyl]-propenoic acid (obtained by condensation of 4-(trans-4-propylcyclohexyl)-benzaldehyde with malonic acid in pyridine) in 120 ml of ethyl acetate is hydrogenated at room temperature and atmospheric pressure, using 4 g of Pd/C (5% Pd) as catalyst. The catalyst is filtered off, and the filtrate is evaporated. Colorless crystals are obtained.

Workup

  1. customis hydrogenated at room temperature
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated
  4. customColorless crystals are obtained

Sources & evidence

ORD record
ord-65b037c534254a04a33f7207ea7f1f6f
Source dataset
uspto-grants-1996_07
Patent number
US05536442

Reaction notes

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