反应详情

(S)-2-[[(S)-2-(Acetoxyacetyl)-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide (3.0 g) obtained in Example 1 was dissolved in water-methanol (1:1, 30 ml) and anhydrous potassium carbonate (1.14 g) were added under ice-cooling. The mixture was stirred at room temperature for 1 hour, and the reaction mixture was concentrated. Methylene chloride was added and the mixture was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated. The residue was dissolved in ethyl acetate, added with active charcoal, stirred at room temperature for 30 minutes, filtered and concentrated to give the title compound (0.81 g) (see Table 1).

1. temperaturecooling
2. concentrationthe reaction mixture was concentrated
3. additionMethylene chloride was added
4. washthe mixture was washed with saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated
7. dissolutionThe residue was dissolved in ethyl acetate
8. additionadded with active charcoal
9. stirringstirred at room temperature for 30 minutes
10. filtrationfiltered
11. concentrationconcentrated