Methane → 5,6-Dihydroxyindole

HRID 1735598Notes

Reaction equation

HRID 1735598 reaction equation
[N+]([C:4]1[CH:9]=[C:8]([O:10]CC2C=CC=CC=2)[C:7]([O:18]CC2C=CC=CC=2)=[CH:6][C:5]=1[CH2:26][C:27]#[N:28])([O-])=O.C.C(O)C>[Pd].O>[OH:18][C:7]1[CH:6]=[C:5]2[C:4](=[CH:9][C:8]=1[OH:10])[NH:28][CH:27]=[CH:26]2

Participants

6

Reactant 3

HCID 297MethaneHCID 702EthanolHCID 10904838[4,5-Bis(benzyloxy)-2-nitrophenyl]acetonitrile

Product 1

HCID 1146835,6-Dihydroxyindole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

The reaction mixture is prepared in an autoclave by adding 0.04 mole (15 g) of 2-nitro-4,5-dibenzyloxyphenylacetonitrile, 1.5 g of palladium at a concentration of 10% on charcoal and 1.5 g of charcoal to 120 ml of ethanol containing 3 ml of water. These are heated to 80° C. for 2 hours, with stirring, under a hydrogen pressure of 4.105Pa. After cooling, the reaction mixture, which is treated in the same manner as previously, produces 5,6-dihydroxyindole in an equivalent yield.

Workup

  1. customThe reaction mixture is prepared in an autoclave
  2. temperatureAfter cooling
  3. additionthe reaction mixture, which is treated in the same manner as previously,

Sources & evidence

ORD record
ord-17f6d0c88da54324bfc869a84d253fa0
Source dataset
uspto-grants-1996_07
Patent number
US05536865

Reaction notes

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