反应详情

温度

120 °C

A mixture of 50 g (0.324 mol) of 2-chloroacetophenone, 104.8 g (0.97 mol) of m-cresol, 45 g (0.326 mol) of potassium carbonate and 1 g of copper is heated at 120° C. for 16 hours. After cooling it is poured into water and extracted twice with methyl tert-butyl ether (MTB ether). The ether phase is washed five times with concentrated sodium hydroxide solution and then twice with water, dried and concentrated. 67.2 g (92% yield) of 2-(3-methylphenoxy)acetophenone remain as yellow oil.

1. temperatureAfter cooling it
2. extractionextracted twice with methyl tert-butyl ether (MTB ether)
3. washThe ether phase is washed five times with concentrated sodium hydroxide solution
4. dry with materialtwice with water, dried
5. concentrationconcentrated