Piperazine, 1-(3-chloropropyl)-4-phenyl- → HCID 13536258, compound

HRID 1735732Notes

Reaction equation

HRID 1735732 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][C:9](=[O:12])[CH:8]([C:13]([O:15][CH3:16])=[O:14])[S:7][C:6]=2[CH:17]=1.[C:18]1([N:24]2[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][CH2:32]Cl)[CH2:26][CH2:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][C:9](=[O:12])[C:8]([CH2:32][CH2:31][CH2:30][N:27]3[CH2:28][CH2:29][N:24]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH2:25][CH2:26]3)([C:13]([O:15][CH3:16])=[O:14])[S:7][C:6]=2[CH:17]=1

Participants

3

Reactant 2

HCID 139197Piperazine, 1-(3-chloropropyl)-4-phenyl-HCID 13536191HCID 13536191, compound

Product 1

HCID 13536258HCID 13536258, compound

Procedure

In the same manner as in Reference Example 1, methyl 7-chloro-3-oxo-3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate was reacted with 3-(4-phenylpiperazin-1-yl)propyl chloride to give methyl 7-chloro-3-oxo-4-[3-(4-phenylpiperazin-1-yl)propyl]3,4-dihydro-2H-1,5-benzoxathiepine-4-carboxylate. When converted to hydrochloride, white crystals were obtained, melting point 197°-199° C.

Sources & evidence

ORD record
ord-357c34ae590d472687827abc5b08aecc
Source dataset
uspto-grants-1996_07
Patent number
US05538974

Reaction notes

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