huagongshe.com
HRID1735739

反应详情

EQUATION

反应方程式

HRID 1735739 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)[O-].[Na+]
HCID517045

Sodium Acetate

C2H3NaO2

结构：C[C@]12CCC(=O)C[C@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C=O)CC[C@]12O
HCID86748908

未命名化合物

结构：N=C(N)NN.O=C(O)O
HCID178513185

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@]12CC[C@H](/C=N/NC(=N)N)[C@@]1(C)CC[C@H]1[C@H]2CC[C@@H]2CC(=O)CC[C@@]21C
HCID178475157

未命名化合物

收率 76.4%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To a solution of 0.13 g of aminoguanidine hydrogencarbonate, 2.00 g of sodium acetate in 25 ml of 0.2M acetic acid a solution of 0.30 g 3-oxo-14β-hydroxy-5β-androstane-17β-carboxaldehyde (Prepn. 5) in 40 ml of dioxane was added dropwise. After 2 hrs the mixture was evaporated to dryness under reduced pressure and the crude product was extracted three times with iso-propanol. Evaporation of the solvent gave 0.30 g of (E)-3-oxo-17β-guanidinoiminomethyl-5β-androstane-14β-ol acetate as a white foam.

WORKUP

后处理

  1. customAfter 2 hrs the mixture was evaporated to dryness under reduced pressure
  2. extractionthe crude product was extracted three times with iso-propanol
  3. customEvaporation of the solvent