Hydrochloric Acid → HCID 70060182, compound

HRID 1735837Notes

Reaction equation

HRID 1735837 reaction equation
[NH2:1][C@@:2]1([C:12]([NH2:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C@H:3]1[OH:11].C(OC([NH:22][C@@H:23]([CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[C@H:24]([OH:39])[C@@H:25]([NH:29][CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=1)[C:26]([OH:28])=[O:27])=O)(C)(C)C.Cl>ClCCl.CO.C(OCC)C>[NH2:1][C@@:2]1([C:12]([NH2:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C@H:3]1[OH:11].[NH2:22][C@@H:23]([CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[C@H:24]([OH:39])[C@@H:25]([NH:29][CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[CH:33][CH:32]=1)[C:26]([OH:28])=[O:27]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 70062102HCID 70062102, compound

Product 1

HCID 70060182HCID 70060182, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

6 g of 4(S)-tert-butoxycarbonylamino-3(S)-hydroxy-2(R)-(4-methoxybenzyl-amino)-5-phenyl-pentanoic acid 1(S)-amino-2(R)-hydroxyindan-amide (compound of Example 1) are dissolved in a mixture of 20 ml of dichloromethane and 4 ml of methanol. 300 ml of a 3 N solution of HCl in diethylether are added and the mixture is stirred for 3 hours at room temperature. The white precipitate is filtered off, washed with diethylether and dried in vacuo. The title compound is obtained in dihydrochloride salt form (m.p.: 147°-151°).

Workup

  1. filtrationThe white precipitate is filtered off
  2. washwashed with diethylether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-1bf7984556ad418bb998db1c38674c88
Source dataset
uspto-grants-1996_07
Patent number
US05538997

Reaction notes

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